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Scirj Volume V, Issue XI, November 2017 Edition
ISSN: 2201-2796

The influence of cyclic feeding regime on the RNA/DNA ratio of the hepatocytes nuclei of young and old rats

Ceasar Dubor Danladi , Nedime Serakinci, Bozkov Anatoli Ivanovich

Abstract: RNA mediates the translation of instructions from DNA into protein. Experimental studies by McCay et al 1935 showed that CR has beneficial effects in longevity, age related diseases, cancer and adaption to stress in rodents. In this study we investigated the effect of CFR a method with CR effects, on the RNA/DNA ratio in the hepatocytes nuclei of 3 months old rats and 20 months old rats. Fasting may enhance health by destroying certain unwanted transcripts and also increasing some that are important, especially those of enzymes involved in some metabolic pathways (Dhahbi et al., 1999) The 3 months old rats results showed an immediate drop to 49% in the RNA/DNA ratio after the first fasting regime as compared to the controls. A further decline to 25% was observed after the first feeding, the second fasting showed an increase to 58% then a subsequent drop to 20% after the second re-feeding. While in 20 months rats a 68% decrease in RNA/DNA ratio was observed after the first fasting period, The fasting- feeding cycle initiated a slight rise to 80% in the DNA/RNA ratio, with a 70% and 77% RNA/DNA ratio following the second fasting and re-feeding cycle.

Reference this Paper: The influence of cyclic feeding regime on the RNA/DNA ratio of the hepatocytes nuclei of young and old rats by Ceasar Dubor Danladi , Nedime Serakinci, Bozkov Anatoli Ivanovich published at: "Scientific Research Journal (Scirj), Volume V, Issue XI, November 2017 Edition, Page 72-79 ".

Search Terms: RNA/DNA ratio, Calorie restriction, chromatin

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