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Scirj Volume II, Issue V, May 2014 Edition
ISSN: 2201-2796

Effects of Pterocarpus Erinaceus Stem Bark Aqueous Extract on Anemic Rats.

Nadro, M.S, Modibbo, A.A

Abstract: The study was designed to evaluate the anti anemic effect of aqueous extract of Pterocarpus erinaceus stem bark in phenylhydrazine induced anemia in albino rats. The extract was also tested for safety. Acute toxicity studies revealed that values up to 5 g/kg body weight did not produced any visible effect. The dosages 250 and 500 mg/kg body weight fed the rats in this study were quite safe. Anemia was induced by administration of 80 mg/kg body weight of phenylhydrazine to the rats. The anemic rats were treated orally with 250 and 500 mg/kg body weight of aqueous extract of Pterocarpus erinaceus stem bark for fourteen days. Oral administration of 250 mg/kg body weight of aqueous extract to anemic rats significantly increased (P< 0.05) serum level of hematological parameters PCV from 40.15 to 54.15, Hb from 11.95 to 13.60, there were significant improvements in RBC, WBC, Neutrophil, Lymphocytes, Platelets, MCV, MCH, and MCHC of the treated rats when compared to the control. Also some serum biochemical parameters were tested. There were significantly reduced (P<0.05) serum levels AST (13.75), ALT (6.67) when compared to control. Similarly, the serum levels of Albumin, bilirubin, Urea, Creatinine and lipid peroxidationsignificantly improve when compare with the control group. The anemic rats fed with 500 mg/kg body weight showed significant improvement in both hematological and biochemical parameters tested. But the difference in values between treated groups (250 and 500 mg/kg body weight) has no significant different. The results suggest that Pterocarpus erinaceus stem bark is safe for use and may use in managing anemia in rats.

Reference this Paper: Effects of Pterocarpus Erinaceus Stem Bark Aqueous Extract on Anemic Rats. by Nadro, M.S, Modibbo, A.A published at: "Scientific Research Journal (Scirj), Volume II, Issue V, May 2014 Edition, Page 1-5 ".

Search Terms: Pterocarpus erinaceus, anemia, phenylhydrazine, stem bark

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