Synthesis, Characterization and Biological Activities of 2, 5-Dimethyl-4-Methoxy[5,6-b]Benzo[2,3-a]Pyrolo-4-Keto Thiazine-1,1-Dioxide by Bodunde Joseph OWOLABI, David Iregbeyaogene IRAOYA, Taiwo Sholagbade ADEPOJU, Scientific Research Journal (Scirj), Volume VII, Issue XII, December 2019 Edition

Scirj Volume VII, Issue XII, December 2019 Edition
ISSN: 2201-2796

Synthesis, Characterization and Biological Activities of 2, 5-Dimethyl-4-Methoxy[5,6-b]Benzo[2,3-a]Pyrolo-4-Keto Thiazine-1,1-Dioxide

Bodunde Joseph OWOLABI, David Iregbeyaogene IRAOYA, Taiwo Sholagbade ADEPOJU

Abstract: Microbial infections remain harrowing menace to health sector globally with distressing effects such as prolonged hospitalization, morbidity and high cost for treatment. The research was conducted to develop effective therapeutic agents against pathogens. Firstly, 2, 5-Dimethyl-4-sulphonyl proline anisole was synthesized from reaction between 2, 5-dimethyl-4-methoxybenzene sulphonyl chloride and L-proline in basic medium. Thereafter, 2, 5-dimethyl-4-methoxy[5,6-b]benzo[2,3-a]pyrolo-4-keto thiazine-1,1-dioxide was synthesized from the intermediate using thionyl chloride and triethyl amine. The synthesized compounds were characterized by FTIR and NMR. Then, antimicrobial activities of the compounds were studied. Both compounds inhibited the growth of tested bacteria and fungi. 2, 5-dimethyl-4-methoxy[5,6-b]benzo[2,3-a]pyrolo-4-keto thiazine-1,1-dioxide gave better antibacterial activities, even than commercial drug while 2, 5-Dimethyl-4-sulphonyl proline anisole exhibited stronger antifungal activities.

Reference this Paper: Synthesis, Characterization and Biological Activities of 2, 5-Dimethyl-4-Methoxy[5,6-b]Benzo[2,3-a]Pyrolo-4-Keto Thiazine-1,1-Dioxide by Bodunde Joseph OWOLABI, David Iregbeyaogene IRAOYA, Taiwo Sholagbade ADEPOJU published at: "Scientific Research Journal (Scirj), Volume VII, Issue XII, December 2019 Edition, Page 25-36 ".

Search Terms: Pathogens, therapeutics, infections, antimicrobials and 2, 5-dimethyl-4-methoxy[5,6-b]benzo[2,3-a]pyrolo-4-keto thiazine-1,1-dioxide

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