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Scirj, Volume VIII [2020]
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Scirj Volume VIII, Issue IV, April 2020 Edition
ISSN: 2201-2796

Comparative expression of adhesion protein N-cadherin in oral lichen planus versus other precancerous and cancerous oral conditions

Heba A. Elhendawy, Doaa AM Esmaeil, Doaa Abdallah Farag

Abstract: Oral Lichen planus (OLP) is a common chronic mucocutaneous disorder with an immune mediated pathogenesis. It is a complex and poorly understood clinical condition with periods of remissions and exacerbations. The risk of malignant transformation of OLP is still a controversial topic. The current study aimed to investigate the role of N-cadherin in OLP by comparing its expression with premalignant oral diseases, oral squamous cell carcinomas and normal oral epithelium. 17 cases of premalignant conditions (oral submucous fibrosis, proliferative verrucous leukoplakia and leukoplakia with dysplasia), 15 cases of erosive ulcerative OLP, 15 cases of OSCC (5 cases from each histologic grade) and 5 cases of normal oral mucosa all were analyzed immunohistochemically for N-cadherin expression. N-cadherin was positively expressed in 47 cases (90.4%) and negative in 5 cases (9.6%). All the studied OSCCs and premalignant lesions demonstrated positive expression. A high statistically significant difference in N-cadherin expression among the studied different OSSC histological grades (P=0.000), OLP and OSCCs (p=0.008), OSCCs and normal oral mucosa (p= 0.000), premalignant lesions and normal oral mucosa (p=0.002). Furthermore, no statistically significant difference between OSCCs and premalignant lesions (p=0.107). Conclusion: N-cadherin can differentiate between behavior of OLP, premalignant lesions and OSCCs.

Reference this Paper: Comparative expression of adhesion protein N-cadherin in oral lichen planus versus other precancerous and cancerous oral conditions by Heba A. Elhendawy, Doaa AM Esmaeil, Doaa Abdallah Farag published at: "Scientific Research Journal (Scirj), Volume VIII, Issue IV, April 2020 Edition, page 63-76 ".

Search Terms: Lichen planus, premalignant lesions, N-cadherin, oral squamous cell carcinoma

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