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Scirj, Volume IV
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Scirj Volume II, Issue IV, April 2014 Edition
ISSN: 2201-2796

Antibacterial, Cytotoxic and Antioxidant activities of Madhuca indica

Israt Jahan Bulbul, Yesmin Begum

Abstract: The research work was conducted on the evaluation of antibacterial, cytotoxic and antioxidant activities of the methanolic extracts of leaf and bark of Madhuca indica (Family- Sapotaceae). Disc diffusion technique was used for in vitro antibacterial screening using kanamycin as standard. Zone of inhibition was observed in disc diffusion against four gram-positive and eight gram-negative pathogenic bacteria. The leaf and bark extracts showed average zone of inhibition ranged from 7-10 mm. Maximum zone of inhibition was observed 10 mm against Bacillus megaterium, Salmonella paratyphi, Vibrio parahemolyticus for barks and Vibrio mimicus for leaves. The cytotoxic activities of crude extracts were determined using Brine shrimp lethality using Vincristine sulfate as standard with LC50 of 8.84µg/ml hence the crude extracts of leaves and barks showed significant cytotoxicity with LC50 of 17.09µg/ml and 45.96 µg/ml respectively. Antioxidant activity test of the crude extracts was assessed by means of DPPH free radical scavenging method where ascorbic acid was used as standard with IC50 value 45.738µg/ml. Leaves and barks of Madhuca indica showed significant antioxidant activity with IC50 value 61.832 µg/ml & 66.342 µg/ml respectively. The phenolic content was found in leaf 62.43mg of GAE / gm of extractives and the amount of phenolic content was 61.08mg of GAE / gm of extractives for bark which correlated with good antioxidant potentiality.

Reference this Paper: Antibacterial, Cytotoxic and Antioxidant activities of Madhuca indica by Israt Jahan Bulbul, Yesmin Begum published at: "Scientific Research Journal (Scirj), Volume II, Issue IV, April 2014 Edition, Page 15-20 ".

Search Terms: Madhuca indica, Anibacterial, Cytotoxicity and Antioxidant Activity

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